U.S. Saw Highest Death Toll Ever In 2021 WHUR Contributor April 13, 2022 at 11:47 am in NEWS Tweet 2021 was the deadliest year in U.S. history – for multiple reasons, according to a new report. 3.465 million deaths were reported in the U.S. last year, the highest single-year death toll in the nation’s history. The biggest cause of the increase was COVID-19 – accounting for 65,000 more deaths than in 2020. Drug overdose deaths also saw a significant spike – especially among young people age 14-18. Deaths from cancer, diabetes, liver disease, and stroke also increased last year. Other than COVID-19, why do you think so many other causes of death increased in 2021? Will they go down in 2022? Tags: cancer, coronavirus, Diabetes, liver disease, U.S. Saw Highest Death Toll Ever In 2021